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KMID : 0043319980210030344
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Archives of Pharmacal Research
1998 Volume.21 No. 3 p.344 ~ p.347
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Isolation of a Multidrug Resistance Inhibitor from Aconitum pseudo-laeve var. erectum
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Kim Dae-Keun
Kwon Hyog-Young
Lee Kang-Ro
Rhee Dong-Kwon
Zee Ok-Pyo
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Abstract
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To overcome multidrug resistance (MDR) in cancer chemotherapy, we prepared various plant extracts and searched for a component which is effective for inhibition of MDR. MDR inhibition activity was determined by measuring cytotoxicity to MDR cells using multidrug resistant human fibrocarcinoma KB V20C, which is resistant to 20 nM vincristine and expresses high level of mdr1 gene. Of various plant extracts, the MeOH extract of the root of Aconitum pseudo-laeve var. erectum was found to have potent inhibitory activity on MDR. The bioassayguided fractionation of the MeOH extract of the plant led to the isolation of an alkaloid, lycaconitine, as an active principle. And the of lycaconitne for KB V20C cells was /ml.
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KEYWORD
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Multidrug Resistance (MDR), Aconitum pseudo-laeve var, erectum, Lycaconitine
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